Abnormal deposition of misprocessed and aggregated proteins is a common final pathway
of most neurodegenerative diseases, including Alzheimer’s disease (AD). AD is …

None of the proposed mechanisms of Alzheimer’s disease (AD) fully explains the distribution
patterns of the neuropathological changes at the cellular and regional levels, and their …

A progressive loss of neurons with age underlies a variety of debilitating neurological
disorders, including Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS), yet few …

CYCLIN-dependent kinase 5 (Cdk5) was originally isolated through its structural homology
to human Cdc2 1 , a key regulator of cell-cycle progression 2–6 . In tissue samples from adult …

Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central
nervous system, including Alzheimer’s disease 1 . The causes leading to such impairment …

MicroRNAs are key regulators of transcriptome plasticity and have been implicated with the
pathogenesis of brain diseases. Here, we employed massive parallel sequencing and …

Aberrant cell-cycle activity and DNA damage are emerging as important pathological components
in various neurodegenerative conditions. However, their underlying mechanisms are …

Exosomes are cellular secretory vesicles containing microRNAs (miRNAs). Once secreted,
exosomes are able to attach to recipient cells and release miRNAs potentially modulating the …

Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental
delay and intellectual disability. To gain insight into the underlying molecular and cellular …

Over the last few years, extracellular vesicles (EVs) have received increasing attention as
potential non-invasive diagnostic and therapeutic biomarkers for various diseases. The …