User profiles for I. Hanganu-Opatz

Ileana Hanganu-Opatz OR Ileana Hanganu OR Ileana L. Hanganu-Opatz

Professor Dev. Neurophysiology
Verified email at zmnh.uni-hamburg.de
Cited by 4554

Between molecules and experience: role of early patterns of coordinated activity for the development of cortical maps and sensory abilities

IL Hanganu-Opatz - Brain research reviews, 2010 - Elsevier
Sensory systems processing information from the environment rely on precisely formed and
refined neuronal networks that build maps of sensory receptor epithelia at different …

Three patterns of oscillatory activity differentially synchronize developing neocortical networks in vivo

JW Yang, IL Hanganu-Opatz, JJ Sun… - Journal of …, 2009 - Soc Neuroscience
Coordinated patterns of electrical activity are important for the early development of sensory
systems. The spatiotemporal dynamics of these early activity patterns and the role of the …

[HTML][HTML] Prefrontal cortex development in health and disease: lessons from rodents and humans

M Chini, IL Hanganu-Opatz - Trends in neurosciences, 2021 - cell.com
The role of the prefrontal cortex (PFC) takes center stage among unanswered questions in
modern neuroscience. The PFC has a Janus-faced nature: it enables sophisticated cognitive …

An increase of inhibition drives the developmental decorrelation of neural activity

M Chini, T Pfeffer, I Hanganu-Opatz - Elife, 2022 - elifesciences.org
Throughout development, the brain transits from early highly synchronous activity patterns to
a mature state with sparse and decorrelated neural activity, yet the mechanisms underlying …

[PDF][PDF] Coupled oscillations mediate directed interactions between prefrontal cortex and hippocampus of the neonatal rat

…, B Pöschel, N Cichon, IL Hanganu-Opatz - Neuron, 2011 - cell.com
The coactivation of prefrontal and hippocampal networks in oscillatory rhythms is critical for
precise information flow in mnemonic and executive tasks, yet the mechanisms governing its …

[HTML][HTML] Subplate cells: amplifiers of neuronal activity in the developing cerebral cortex

HJ Luhmann, W Kilb, I Hanganu-Opatz - Frontiers in neuroanatomy, 2009 - frontiersin.org
Due to their unique structural and functional properties, subplate cells are ideally suited to
function as important amplifying units within the developing neocortical circuit. Subplate …

Increased resting-state gamma-band connectivity in first-episode schizophrenia

…, G Leicht, N Polomac, IL Hanganu-Opatz… - Schizophrenia …, 2015 - academic.oup.com
Background: Schizophrenia has long been suggested to represent a disorder with prominent
neural dysconnectivity. Gamma-band oscillations are highly relevant in this context, due …

[HTML][HTML] Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

…, M Schweizer, JP Lerch, IL Hanganu-Opatz… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental
disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several …

Resting-state connectivity in the prodromal phase of schizophrenia: insights from EEG microstates

…, D Schoettle, N Polomac, IL Hanganu-Opatz… - Schizophrenia …, 2014 - Elsevier
Introduction Resting-state EEG microstates are thought to reflect the momentary local states
and interactions of distributed neural networks in the brain. Several changes in resting-state …

Treatment during a vulnerable developmental period rescues a genetic epilepsy

…, I Jakovcevski, A Ivanov, IL Hanganu-Opatz… - Nature medicine, 2015 - nature.com
The nervous system is vulnerable to perturbations during specific developmental periods.
Insults during such susceptible time windows can have long-term consequences, including the …