We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

JohnA. Eddy zero. In contrast, in the years around a sunspot maximum there is seldom a
day wh~ na number of spots cannot be seen, and often hundreds are present. Past counts of …

Long-term changes in the level of solar activity are found in historical records and in fossil
radiocarbon in tree-rings. Typical of these changes are the Maunder Minimum (AD 1645–1715…

In the originally published version of this article, the authors neglected to include Younes
Mokrab and Aaron M. Newman as co-authors and misspelled the names of authors Charles S. …

Anti-inflammatory strategies are proposed to have beneficial effects in Alzheimer's disease.
To explore how anti-inflammatory cytokine signaling affects Aβ pathology, we investigated …

Extracellular cues affect signaling, metabolic, and regulatory processes to elicit cellular
responses. Although intracellular signaling, metabolic, and regulatory networks are highly …

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical
advances by enabling the responsible sharing of clinical and genomic data through both …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Background Human tissues perform diverse metabolic functions. Mapping out these tissue-specific
functions in genome-scale models will advance our understanding of the metabolic …