The circadian system of mammals is composed of a hierarchy of oscillators that function at
the cellular, tissue, and systems levels. A common molecular mechanism underlies the cell-…

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of the master circadian
pacemaker in mammals. The individual cells of the SCN are capable of functioning …

Period determination in the mammalian circadian clock involves the turnover rate of the
repressors CRY and PER. We show that CRY ubiquitination engages two competing E3 ligase …

Mammalian circadian organization is governed by pacemaker neurons in the brain that
communicate with oscillators in peripheral tissues. Adrenal glucocorticoids are important time-…

In mammals, a pacemaker in the suprachiasmatic nucleus (SCN) is thought to be required
for behavioral, physiological, and molecular circadian rhythms. However, there is …

The “master clock” in the suprachiasmatic nucleus (SCN) of the hypothalamus controls most
behavioral, physiological, and molecular circadian rhythms in mammals. However, there are …

Previous studies have demonstrated a positive correlation between glucocorticoid levels and
circadian reentrainment time following a shift in the light:dark (LD) cycle. We conducted a …

Transcriptional regulation of numerous interferon-regulated genes, including Toll-like receptor
3 (Tlr3), which encodes an innate immune sensor of viral double-stranded RNA, depends …

Atemporary loss of normal circadian entrainment, such as that associated with shift work
and transmeridian travel, can result in an array of detrimental symptoms, making rapid …

Background: Atopic dermatitis (AD) affects 2%–10% of adults worldwide. Occurrence and
severity of symptoms and treatment success vary among patients. Objective: To determine …