Since their initial recognition 20 years ago, Shiga toxin-producing Escherichia coli (STEC)
strains have emerged as an important cause of serious human gastrointestinal disease, which …

Streptococcus pneumoniae is a Gram-positive bacterial pathogen that colonizes the mucosal
surfaces of the host nasopharynx and upper airway. Through a combination of virulence-…

Streptococcus pneumoniae has a complex relationship with its obligate human host. On the
one hand, the pneumococci are highly adapted commensals, and their main reservoir on the …

Shiga toxigenic Escherichia coli (STEC) comprises a diverse group of organisms capable of
causing severe gastrointestinal disease in humans. Within the STEC family, certain strains …

Streptococcus pneumoniae is one of the leading causes of invasive bacterial disease
worldwide. Fragments of the cell wall and the cytolytic toxin pneumolysin have been shown to …

Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption
causes ER stress and augments disease. ER stress activates the unfolded protein response (…

AB 5 toxins are produced by pathogenic bacteria and consist of enzymatic A subunits that
corrupt essential eukaryotic cell functions, and pentameric B subunits that mediate uptake into …

We recently described a novel megaplasmid-encoded adhesin produced by certain Shiga
toxigenic Escherichia coli (STEC) strains that lack the locus for enterocyte effacement (LEE) …

Sera were analyzed by radioimmunoassay for type-specific pneumococcal antibody in 249
children aged six to 54 months, who were participating in a controlled trial of a 14-valent …

The capacity of Shiga toxigenic Escherichia coli(STEC) to adhere to the intestinal mucosa
undoubtedly contributes to pathogenesis of human disease. The majority of STEC strains …