We have investigated the use of a cationic lipid preparation to enhance antisense oligonucleotide
activity in human umbilical vein endothelial cells. A liposomal preparation containing …

Host factors required for viral replication are ideal drug targets because they are less likely
than viral proteins to mutate under drug-mediated selective pressure. Although genome-wide …

Background Influenza is a common infectious disease caused by influenza viruses. Annual
epidemics cause severe illnesses, deaths, and economic loss around the world. To better …

Background Interpreting in vivo sampled microarray data is often complicated by changes in
the cell population demographics. To put gene expression into its proper biological context, …

Seasonal influenza A viruses cause annual epidemics of respiratory disease; highly pathogenic
avian H5N1 and the recently emerged H7N9 viruses cause severe infections in humans…

We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

Interactions of proteins regulate signaling, catalysis, gene expression and many other cellular
functions. Therefore, characterizing the entire human interactome is a key effort in current …

The 2019 novel coronavirus, SARS-CoV-2, is an emerging pathogen of critical significance
to international public health. Knowledge of the interplay between molecular-scale virus-…

Occasional transmission of highly pathogenic avian H5N1 influenza viruses to humans
causes severe pneumonia with high mortality. To better understand the mechanisms via which …

Genome-wide transcriptional profiling provides a global view of cellular state and how this
state changes under different treatments (eg drugs) or conditions (eg healthy and diseased). …