Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.
Although these structures were first described more than a century ago, the full scope of …

Motile and non-motile (primary) cilia are nearly ubiquitous cellular organelles. The dysfunction
of cilia causes diseases known as ciliopathies. The number of reported ciliopathies (…

Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …

The unanticipated involvement of several intraflagellar transport proteins in the mammalian
Hedgehog (Hh) pathway has hinted at a functional connection between cilia and Hh signal …

Nephronophthisis (NPHP), Joubert (JBTS), and Meckel-Gruber (MKS) syndromes are
autosomal-recessive ciliopathies presenting with cystic kidneys, retinal degeneration, and …

Mutations affecting ciliary components cause ciliopathies. As described here, we investigated
Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is essential …

… Cheyette, and members of the Reiter lab for helpful discussions. Support for microscopy
was provided by the NIH (P30 DK063720). This work was supported by funding from the NSF (…

… Evan and the members of the Reiter lab for critical reading of this manuscript; K. Thorn and
the UCSF Nikon Imaging Center for assistance with confocal microscopy; C. Miller and JD …

The mechanisms regulating vertebrate heart and endoderm development have recently
become the focus of intense study. Here we present evidence from both loss- and gain-of-…

Alternative splicing is prevalent in the mammalian brain. To interrogate the functional role of
alternative splicing in neural development, we analyzed purified neural progenitor cells (…