Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical impact in improving
overall survival of several malignancies associated with poor outcomes; however, only 20…

Novel developments in biomarkers discovery are essential in modern health care, notably
in treatment individualization and precision medicine. Clinical metabolomics, which aims to …

The emergence of antimicrobial resistance (AMR) in bacterial pathogens represents a global
health threat. The metabolic state of bacteria is associated with a range of genetic and …

Collateral sensitivity (CS)-based antibiotic treatments, where increased resistance to one
antibiotic leads to increased sensitivity to a second antibiotic, may have the potential to limit the …

The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI)
treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, …

Aims The enzymatic activity of dihydropyrimidine dehydrogenase (DPD) and thymidylate
synthase (TS) are important for the tolerability and efficacy of the fluoropyrimidine drugs. In the …

Creating a cDNA library for deep mRNA sequencing (mRNAseq) is generally done by
random priming, creating multiple sequencing fragments along each transcript. A 3′-end-focused …

Background The objective of this analysis was to determine the factors associated with early
onset treatment-related toxicity in patients treated with capecitabine-based anticancer …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • The cholinergic system is important
for different central nervous system functions, including memory, learning and attention. …