Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

Characterizing the multifaceted contribution of genetic and epigenetic factors to disease
phenotypes is a major challenge in human genetics and medicine. We carried out high-…

Background Autoimmune disease-associated variants are preferentially found in regulatory
regions in immune cells, particularly CD4 + T cells. Linking such regulatory regions to gene …

Linking non-coding genetic variants associated with the risk of diseases or disease-relevant
traits to target genes is a crucial step to realize GWAS potential in the introduction of …

Conventional CRISPR approaches for precision genome editing rely on the introduction of
DNA double-strand breaks (DSB) and activation of homology-directed repair (HDR), which is …

Transcriptional profiling of hematopoietic cell subpopulations has helped to characterize the
developmental stages of the hematopoietic system and the molecular bases of malignant …

A series of synthetic five-year return period storms having rectangular, triangular and
bimodal (triangular) temporal profiles was compiled from depthduration-frequency (DDF) …

Background This work is aimed at improving the understanding of cardiometabolic syndrome
pathophysiology and its relationship with thrombosis by generating a multi-omic disease …

Transcriptional profiling of hematopoietic cell subpopulations has helped characterize the
developmental stages of the hematopoietic system and the molecular basis of malignant and …

Gene editing technologies hold promise for enabling the next generation of adoptive cellular
therapies. Conventional gene editing platforms that rely on nuclease activity, such as …