[HTML][HTML] XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks
JK Horton, M Watson, DF Stefanick, DT Shaughnessy… - Cell research, 2008 - nature.com
Single-strand breaks (SSBs) can occur in cells either directly, or indirectly following initiation
of base excision repair (BER). SSBs generally have blocked termini lacking the …
of base excision repair (BER). SSBs generally have blocked termini lacking the …
Eukaryotic base excision repair: new approaches shine light on mechanism
WA Beard, JK Horton, R Prasad… - Annual review of …, 2019 - annualreviews.org
Genomic DNA is susceptible to endogenous and environmental stresses that modify DNA
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
structure and its coding potential. Correspondingly, cells have evolved intricate DNA repair …
Requirement of mammalian DNA polymerase-β in base-excision repair
SYNTHESIS of DNA by DNA polymerase-β is distributive on single-stranded DNA templates,
but short DNA gaps with a 5′ PO 4 in the gap are filled processively to completion 1,2 . In …
but short DNA gaps with a 5′ PO 4 in the gap are filled processively to completion 1,2 . In …
The lyase activity of the DNA repair protein β-polymerase protects from DNA-damage-induced cytotoxicity
…, R Prasad, A Evenski, A Baker, XP Yang, JK Horton… - Nature, 2000 - nature.com
Small DNA lesions such as oxidized or alkylated bases are repaired by the base excision
repair (BER) pathway 1 . BER includes removal of the damaged base by a lesion-specific DNA …
repair (BER) pathway 1 . BER includes removal of the damaged base by a lesion-specific DNA …
Management of the axilla in early-stage breast cancer: Ontario Health (Cancer Care Ontario) and ASCO guideline
…, IS Dayes, J Engel, JK Horton… - Journal of Clinical …, 2021 - ingentaconnect.com
PURPOSE To provide recommendations on the best strategies for the management and on
the best timing and treatment (surgical and radiotherapeutic) of the axilla for patients with …
the best timing and treatment (surgical and radiotherapeutic) of the axilla for patients with …
Breast cancer biology: clinical implications for breast radiation therapy
Historically, prognosis and treatment decision making for breast cancer patients have been
dictated by the anatomic extent of tumor spread. However, in recent years, “breast cancer” …
dictated by the anatomic extent of tumor spread. However, in recent years, “breast cancer” …
Magnetic resonance imaging as a predictor of pathologic response in patients treated with neoadjuvant systemic treatment for operable breast cancer: Translational …
…, A Cantor, KD Amos, A Forero, M Golshan, JK Horton… - Cancer, 2013 - Wiley Online Library
BACKGROUND: Increased pathologic complete response (pCR) rates observed with
neoadjuvant chemotherapy (NCT) for some subsets of patients with invasive breast cancer have …
neoadjuvant chemotherapy (NCT) for some subsets of patients with invasive breast cancer have …
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected …
E Schneider, JK Horton, CH Yang, M Nakagawa… - Cancer research, 1994 - AACR
A human breast cancer cell line (MCF7/WT) was selected for resistance to etoposide (VP-16)
by stepwise exposure to 2-fold increasing concentrations of this agent. The resulting cell …
by stepwise exposure to 2-fold increasing concentrations of this agent. The resulting cell …
[HTML][HTML] Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate: Evidence for the role of poly (ADP-ribose) polymerase-1 in DNA …
To examine the interaction of mammalian base excision repair (BER) enzymes with DNA
intermediates formed during BER, we used a novel photoaffinity labeling probe and mouse …
intermediates formed during BER, we used a novel photoaffinity labeling probe and mouse …
[HTML][HTML] Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses
…, DF Joyce, BP Engelward, JK Horton… - Journal of Biological …, 2003 - ASBMB
DNA alkylation damage is primarily repaired by the base excision repair (BER) machinery in
mammalian cells. In repair of the N-alkylated purine base lesion, for example, alkyl adenine …
mammalian cells. In repair of the N-alkylated purine base lesion, for example, alkyl adenine …