Synthetic biology was founded as a biophysical discipline that sought explanations for the
origins of life from chemical and physical first principles. Modern synthetic biology has been …

Motivation: This article presents libRoadRunner, an extensible, high-performance, cross-platform,
open-source software library for the simulation and analysis of models expressed …

Here we present Tellurium, a Python-based environment for model building, simulation, and
analysis that facilitates reproducibility of models in systems and synthetic biology. Tellurium …

Physical inactivity is a scourge to human health, promoting metabolic disease and muscle
wasting. Interestingly, multiple ecological niches have relaxed investment into physical activity…

The considerable difficulty encountered in reproducing the results of published dynamical
models limits validation, exploration and reuse of this increasingly large biomedical research …

Objective: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering,
and medicine. However, substantial work remains to create accurate comprehensive …

Computational models have great potential to accelerate bioscience, bioengineering, and
medicine. However, it remains challenging to reproduce and reuse simulations, in part, …

… JK Medley was supported by the National Institutes of Health under Grant R01 GM081070
and the National Science Foundation under Grant 1355909. AP Goldberg was supported by …

Insights from organisms, which have evolved natural strategies for promoting survivability
under extreme environmental pressures, may help guide future research into novel …

In this article, we present Tellurium, a powerful Python-based integrated environment
designed for model building, analysis, simulation and reproducibility in systems and synthetic …