Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

Sequence-based variation in gene expression is a key driver of disease risk. Common
variants regulating expression in cis have been mapped in many expression quantitative trait …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic …

Background The influence of genetic variation on complex diseases is potentially mediated
through a range of highly dynamic epigenetic processes exhibiting temporal variation during …

While there have been studies exploring regulatory variation in one or more tissues, the
complexity of tissue-specificity in multiple primary tissues is not yet well understood. We explore …

… For single-nucleotide variants sites a truth sensitivity of 99.5%, which corresponded to a
minimum … For INDEL sites a truth sensitivity of 97%, which corresponded to a minimum VQSLOD …

Epigenetic modifications such as DNA methylation play a key role in gene regulation and
disease susceptibility. However, little is known about the genome-wide frequency, localization, …

… The authors wish it to be known that JL Min and G. Hemani authors contributed equally. …
The authors wish it to be known that JL Min and G. Hemani authors contributed equally. …

… Research into Ageing and the Arthritis Research Campaign supported the research of JL
Finally, we thank Eka Suchiman for additional genotyping and Hein Putter for performing …