Despite the many approaches to study differential splicing from RNA-seq, many challenges
remain unsolved, including computing capacity and sequencing depth requirements. Here …

Alternative splicing plays an essential role in many cellular processes and bears major
relevance in the understanding of multiple diseases, including cancer. High-throughput RNA …

The tumor immune microenvironment is a main contributor to cancer progression and a
promising therapeutic target for oncology. However, immune microenvironments vary profoundly …

Brain metastases are the most common tumor of the brain with a dismal prognosis. A fraction
of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors (…

CD19-directed immunotherapies have revolutionized the treatment of advanced B-cell acute
lymphoblastic leukemia (B-ALL). Despite initial impressive rates of complete remission (CR…

Background Phenotypic changes during cancer progression are associated with alterations
in gene expression, which can be exploited to build molecular signatures for tumor stage …

Leukemia stem cells (LSCs) share numerous features with healthy hematopoietic stem cells
(HSCs). G-protein coupled receptor family C group 5 member C (GPRC5C) is a regulator of …

B-cell acute lymphoblastic leukemia (ALL; B-ALL) is the most common pediatric cancer, and
high hyperdiploidy (HyperD) identifies the most common subtype of pediatric B-ALL. …

The interactions between tumor and immune cells along the course of breast cancer
progression remain largely unknown. Here, we extensively characterize multiple sequential and …

Chromosomal instability (CIN) lies at the core of cancer development leading to aneuploidy,
chromosomal copy-number heterogeneity (chr-CNH) and ultimately, unfavorable clinical …