… Here we illustrate this kind of discussion by focusing on some recent results of Socci and
Onuchic which find evidence for specific features arising from energy landscape analysis.” In …

… Lattice simulations by Socci & Onuchic support this notion (54). An important qualitative
result of their analysis was that the search difficulties that can only occur because of landscape …

… Onuchic et aI. look at real protein folding by developing a law of corresponding states (2). …
Similarly, Onuchic et al. argue that the detailed local structural features like the hydrogen …

… Other global trends of folding are predicted by purely analytical treatments, as reviewed by
Plotkin and Onuchic 37., 38.. Free energy functional schemes based on polymer theory 39., …

The similarity in the three-dimensional structures of homologous proteins imposes strong
constraints on their sequence variability. It has long been suggested that the resulting …

The rate of long-distance electron transfer in proteins rapidly decreases with distance,
which is indicative of an electron tunneling process. Calculations predict that the distance …

Recent experimental results suggest that the native fold, or topology, plays a primary role in
determining the structure of the transition state ensemble, at least for small, fast-folding …

A lattice model of protein folding is developed to distinguish between amino acid sequences
that do and do not fold into unique conformations. Although Monte Carlo simulations …

… Using the replica exchange method, Garcia & Onuchic (57) mapped the free-energy
landscape for folding of fragment B of protein A of Staphylococcus aureus in explicit water, …

In biological and chemical electron transfer, a nuclear reaction coordinate is coupled to
other nuclear and/or ‘‘solvent’’ coordinates. This coupling, or friction, if strong enough, may …