[PDF][PDF] Playing the end game: DNA double-strand break repair pathway choice
DNA double-strand breaks (DSBs) are highly toxic lesions that can drive genetic instability.
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …
To preserve genome integrity, organisms have evolved several DSB repair mechanisms, of …
[HTML][HTML] KDIGO clinical practice guideline for the care of kidney transplant recipients: a summary
The 2009 Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline
on the monitoring, management, and treatment of kidney transplant recipients is intended to …
on the monitoring, management, and treatment of kidney transplant recipients is intended to …
Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data
Objective To compare the positive and negative effects of tacrolimus and ciclosporin as initial
treatment for renal transplant recipients. Design Systematic review. Data sources and study …
treatment for renal transplant recipients. Design Systematic review. Data sources and study …
[HTML][HTML] The natural history of chronic allograft nephropathy
…, PJ O'Connell, RDM Allen, JR Chapman - … England Journal of …, 2003 - Mass Medical Soc
Background With improved immunosuppression and early allograft survival, chronic allograft
nephropathy has become the dominant cause of kidney-transplant failure. Methods We …
nephropathy has become the dominant cause of kidney-transplant failure. Methods We …
Cancer incidence before and after kidney transplantation
… Financial Disclosures: Dr Chapman reports being on advisory boards and speaker panels
for Astellas, Novartis, Wyeth, and Hoffmann la Roche, and receiving research support from the …
for Astellas, Novartis, Wyeth, and Hoffmann la Roche, and receiving research support from the …
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
NK Kolas, JR Chapman, S Nakada, J Ylanko… - Science, 2007 - science.org
Cells respond to DNA double-strand breaks by recruiting factors such as the DNA-damage
mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer …
mediator protein MDC1, the p53-binding protein 1 (53BP1), and the breast cancer …
Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation
…, EF Reed, RA Bray, P Campbell, JR Chapman… - …, 2013 - journals.lww.com
Background The introduction of solid-phase immunoassay (SPI) technology for the detection
and characterization of human leukocyte antigen (HLA) antibodies in transplantation while …
and characterization of human leukocyte antigen (HLA) antibodies in transplantation while …
[PDF][PDF] RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection
JR Chapman, P Barral, JB Vannier, V Borel, M Steger… - Molecular cell, 2013 - cell.com
The appropriate execution of DNA double-strand break (DSB) repair is critical for genome
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
stability and tumor avoidance. 53BP1 and BRCA1 directly influence DSB repair pathway …
DNA helicases Sgs1 and BLM promote DNA double-strand break resection
S Gravel, JR Chapman, C Magill… - Genes & …, 2008 - genesdev.cshlp.org
A key cellular response to DNA double-strand breaks (DSBs) is 5′-to-3′ DSB resection
by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling …
by nucleases to generate regions of ssDNA that then trigger cell cycle checkpoint signaling …
Factors affecting the pullout strength of cancellous bone screws
JR Chapman, RM Harrington, KM Lee… - 1996 - asmedigitalcollection.asme.org
Screws placed into cancellous bone in orthopedic surgical applications, such as fixation of
fractures of the femoral neck or the lumbar spine, can be subjected to high loads. Screw …
fractures of the femoral neck or the lumbar spine, can be subjected to high loads. Screw …