… Siewen, JR. and Hofler, H. Analysis for microsalellite instabilily and mutations of the DNA
mis match … Eshleman. JR. and Markowilz. SD Mismalch repair defecls in human carcinogenesis.…

Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …

Mismatch repair defects are carcinogenic. This conclusion comes some 80 years after the
original description of a type of familial colorectal cancer in which mismatch repair defects are …

Background Somatic mutations have the potential to encode “non-self” immunogenic antigens.
We hypothesized that tumors with a large number of somatic mutations due to mismatch-…

The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of
somatic mutations. In a proof-of-concept study, we previously showed that colorectal …

… Contact information for the authors who directed the major components of this project is
as follows: JR Eshleman, SE Kern (clinical and sample coordination), [email protected], [email …

Integrated genomic analysis of 456 pancreatic ductal adenocarcinomas identified 32 recurrently
mutated genes that aggregate into 10 pathways: KRAS, TGF-β, WNT, NOTCH, ROBO/…

Metastasis, the dissemination and growth of neoplastic cells in an organ distinct from that in
which they originated 1 , 2 , is the most common cause of death in cancer patients. This is …

More than 2% of the adult US population harbors a pancreatic cyst. These often pose a difficult
management problem because conventional criteria cannot always distinguish cysts with …

Activation of the Hedgehog (Hh) signalling pathway by sporadic mutations or in familial
conditions such as Gorlin's syndrome is associated with tumorigenesis in skin, the cerebellum …