Cells, the basic units of biological structure and function, vary broadly in type and state.
Single-cell genomics can characterize cell identity and function, but limitations of ease and scale …

Neurons have diverse molecular, morphological, connectional and functional properties. We
believe that the only realistic way to manage this complexity — and thereby pave the way …

To analyze cell lineage in the murine cerebral cortex, we infected progenitor cells with a
recombinant retrovirus, then used the retroviral gene product to identify the descendants of …

▪ Abstract We describe the formation, maturation, elimination, maintenance, and regeneration
of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses. The NMJ …

The postsynaptic apparatus of the skeletal neuromuscular junction, like that of other synapses,
contains a high-density patch of neurotransmitter receptors that is closely associated with …

A simplification of the laminin nomenclature is presented. Laminins are multidomain heterotrimers
composed of α, β and γ chains. Previously, laminin trimers were numbered with Arabic …

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins (together
termed XFPs) were selectively expressed in neurons. All four XFPs labeled neurons in …

Do new synapses form in the adult cortex to support experience-dependent plasticity? To
address this question, we repeatedly imaged individual pyramidal neurons in the mouse barrel …

Detailed analysis of neuronal network architecture requires the development of new methods.
Here we present strategies to visualize synaptic circuits by genetically labelling neurons …

The cellular basis of age-related behavioral decline remains obscure but alterations in
synapses are likely candidates. Accordingly, the beneficial effects on neural function of caloric …