User profiles for J. W. Holloway

John W. Holloway

University of Southampton
Verified email at soton.ac.uk
Cited by 24347

Genetics of allergic disease

JW Holloway, IA Yang, ST Holgate - Journal of Allergy and Clinical …, 2010 - Elsevier
Allergic diseases are complex genetic diseases resulting from the effect of multiple genetic
and interacting environmental factors on their pathophysiology. Recent years have seen …

The genetic basis of atopic asthma.

JW Holloway, B Beghe, ST Holgate - Clinical and Experimental …, 1999 - iris.unimore.it
Asthma is a respiratory disease characterized by recurrentrespiratory symptoms, reversible
variable airway obstruction,airway inflammation and increased airway responsiveness. …

Genetic susceptibility to the respiratory effects of air pollution

…, ST Holgate, JW Holloway - Postgraduate …, 2009 - academic.oup.com
There is large variation between individuals in their response to air pollutants. This review
summarises the existing evidence that genetic factors influence the mechanisms of lung injury …

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

…, FM Cuss, S Rorke, JB Clough, JW Holloway… - Nature, 2002 - nature.com
Asthma is a common respiratory disorder characterized by recurrent episodes of coughing,
wheezing and breathlessness. Although environmental factors such as allergen exposure …

Genome-wide association study identifies five loci associated with lung function

…, JR Britton, RW Morris, JW Holloway… - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations

…, PM Lackie, VWV Jaddoe, A Simpson, JW Holloway… - Nature …, 2014 - nature.com
Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

[HTML][HTML] Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

…, AS Havulinna, A Hofman, R Holle, JW Holloway… - PLoS …, 2009 - journals.plos.org
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis
of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult …

Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

…, BA Raby, A Simpson, B Jacobsson, JW Holloway… - Nature …, 2015 - nature.com
Genetic association studies have identified 21 loci associated with atopic dermatitis risk
predominantly in populations of European ancestry. To identify further susceptibility loci for this …

Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

KJ Erb, JW Holloway, A Sobeck, H Moll… - The Journal of …, 1998 - rupress.org
It has been proposed that the increase in prevalence and severity of atopic disorders
inversely correlates with exposure to infectious diseases such as tuberculosis. We have …

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

…, CE Pennell, F Nyberg, D Kuh, JW Holloway… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …