Aims/hypothesis Insulin controls glucose metabolism via multiple signalling pathways,
including the phosphatidylinositol 3-kinase (PI3K) pathway in muscle and adipose tissue. The …

Growth factor receptor tyrosine kinase ( RTK ) pathway activation is a key mechanism for
mediating cancer growth, survival, and treatment resistance. Cognate ligands play crucial roles …

The effect of 2 formulations of Bacillus thuringiensis subsp. kurstaki (Foray 48B and Dipel
8AF) was evaluated on 42 species of native Lepidoptera in laboratory bioassays using instars …

The roles of protein-tyrosine phosphatases (PTPs) in processes such as cell growth and
adhesion are poorly understood. To explore the ability of specific PTPs to regulate cell signaling …

BACKGROUND Progression to a lethal androgen‐independent (AI) stage of advanced
prostate cancer is a critical clinical obstacle limiting patient survival. PTEN inactivation is …

The secondary attractant for the smaller European elm bark beetleScolytus multistriatus is a
mixture of three compounds: (-)4-methyl-3-heptanol(I); 2,4-dimethyl-5-ethyl-6,8-dioxabicyclo(…

Nontarget effects of a single aerial application of Bacillus thuringiensis at 90 BIU/ha were
studied on native Lepidoptera in west central Virginia in 1992 (treatment year) and in 1993 and …

A point mutation in the mRNA of NADP (H): quinone oxidoreductase 1 (NQO1, DT-diaphorase)
is believed to be responsible for reduced enzyme activity in the adenocarcinoma BE cell …

Prostate cancer (PCa) is among the most commonly-occurring cancers worldwide and a leader
in cancer-related deaths. Local non-invasive PCa is highly treatable but limited treatment …

Heat shock protein 27 (Hsp27) is emerging as a promising therapeutic target for treatment
of various cancers. Although the role of Hsp27 in protection from stress-induced intrinsic cell …