User profiles for J. Alcami

Jose Alcami

Instituto de Salud Carlos III
Verified email at isciii.es
Cited by 11565

Understanding HIV-1 latency provides clues for the eradication of long-term reservoirs

…, M Perez-Olmeda, J Alcamí - Nature Reviews …, 2009 - nature.com
HIV-1 can infect both activated and resting, non-dividing cells, following which the viral genome
can be permanently integrated into a host cell chromosome. Latent HIV-1 reservoirs are …

[HTML][HTML] Overview of SARS-CoV-2 infection in adults living with HIV

…, MA Marcos, E Martínez, S Bertagnolio, J Alcamí… - The lancet HIV, 2021 - thelancet.com
Around 2·5 million deaths and more than 110 million COVID-19 cases have been reported
globally. Although it initially appeared that HIV infection was not a risk factor for COVID-19 or …

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

…, N Chomont, KJ Bar, XG Yu, M Lichterfeld, J Alcami… - Nature medicine, 2020 - nature.com
Therapeutic strategies are being clinically tested either to eradicate latent HIV reservoirs or
to achieve virologic control in the absence of antiretroviral therapy. Attaining this goal will …

[HTML][HTML] Immunogenicity and reactogenicity of BNT162b2 booster in ChAdOx1-S-primed participants (CombiVacS): a multicentre, open-label, randomised, controlled …

…, J Ochando, J Alcamí, C Belda-Iniesta, J Frías… - The Lancet, 2021 - thelancet.com
Background To date, no immunological data on COVID-19 heterologous vaccination schedules
in humans have been reported. We assessed the immunogenicity and reactogenicity of …

[HTML][HTML] Membrane raft microdomains mediate lateral assemblies required for HIV‐1 infection

…, S Sánchez‐Palomino, R Delgado, J Alcamí… - EMBO …, 2000 - embopress.org
HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope
with cell surface receptors. We show that these membrane changes are necessary for …

Absolute dependence on kappa B responsive elements for initiation and Tat‐mediated amplification of HIV transcription in blood CD4 T lymphocytes.

J Alcami, T Lain de Lera, L Folgueira… - The EMBO …, 1995 - embopress.org
… DNA in resting CD4 lymphocytes and J-Jhan cells. CD4 T lymphocytes or J-Jhan cells were
… myelomonocytic cells (Arenzana-Seisdedos and Alcami, unpublished results) In order to …

[HTML][HTML] Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells

MC Iglesias-De La Cruz, P Ruiz-Torres, J Alcamí… - Kidney international, 2001 - Elsevier
… Carmen Iglesias-de la Cruz , Piedad Ruiz-Torres , José Alcamí , Luisa Díez-Marqués ,
Rocío Ortega-Velázquez , Sheldon Chen , Manuel Rodríguez-Puyol , Fuad N. Ziyadeh , Diego …

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the α subunit of eukaryotic translation initiation factor 2 and NF-κB

J Gil, J Alcamí, M Esteban - Molecular and cellular biology, 1999 - Taylor & Francis
The double-stranded (ds) RNA-dependent protein kinase (PKR) is a key mediator of antiviral
effects of interferon (IFN) and an active player in apoptosis induced by different stimuli. The …

Human cytomegalovirus infection induces transcription and secretion of transforming growth factor beta 1

S Michelson, J Alcami, SJ Kim, D Danielpour… - Journal of …, 1994 - Am Soc Microbiol
Human cytomegalovirus (CMV) infection can elicit a transitory, but profound,
immunodepression in immunocompetent individuals. Cytopathogenic destruction of CMV-infected …

Genomic organization and promoter characterization of human CXCR4 gene 1

A Caruz, M Samsom, JM Alonso, J Alcami… - FEBS …, 1998 - Wiley Online Library
CXCR4 is the receptor for the CXC chemokine SDF1 that has essential functions on embryo
organogenesis, immunological functions and T lymphocyte trafficking. Recently, CXCR4 …