[PDF][PDF] Enhanced delivery of antibodies across the blood-brain barrier via TEMs with inherent receptor-mediated phagocytosis
…, A LaCombe, Z Ainekulu, E Lacy, J Aligo, J Ho… - Med, 2022 - cell.com
… the fastest clearance for TAU-TfR-J-WT followed by TAU-TfR-J-mut, whereas both TAU-TfR-…
for TAU-TfR-J-WT resulting from TfR-driven TMDD in the periphery. TAU-TfR-J-mut had a …
for TAU-TfR-J-WT resulting from TfR-driven TMDD in the periphery. TAU-TfR-J-mut had a …
[HTML][HTML] Endocytic Rab proteins are required for hepatitis C virus replication complex formation
D Manna, J Aligo, C Xu, WS Park, H Koc, W Do Heo… - Virology, 2010 - Elsevier
During infection, hepatitis C virus (HCV) NS4B protein remodels host membranes to form HCV
replication complexes (RC) which appear as foci under fluorescence microscopy (FM). To …
replication complexes (RC) which appear as foci under fluorescence microscopy (FM). To …
[PDF][PDF] Staphylococcus aureus leukocidins target endothelial DARC to cause lethality in mice
The pathogenesis of Staphylococcus aureus is thought to depend on the production of pore-forming
leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin …
leukocidins that kill leukocytes and lyse erythrocytes. Two leukocidins, Leukocidin …
[HTML][HTML] Bovine viral diarrhea virus NS4B protein is an integral membrane protein associated with Golgi markers and rearranged host membranes
E Weiskircher, J Aligo, G Ning, KV Konan - Virology journal, 2009 - Springer
Background Very little is known about BVDV NS4B, a protein of approximately 38 kDa. However,
a missense mutation in NS4B has been implicated in changing BVDV from a cytopathic …
a missense mutation in NS4B has been implicated in changing BVDV from a cytopathic …
Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis
M Sun, TA Rothermel, L Shuman, JA Aligo… - Journal of …, 2004 - Am Soc Microbiol
The paramyxovirus family includes many well-known human and animal pathogens as well
as emerging viruses such as Hendra virus and Nipah virus. The V protein of simian virus 5 (…
as emerging viruses such as Hendra virus and Nipah virus. The V protein of simian virus 5 (…
[HTML][HTML] Formation and function of hepatitis C virus replication complexes require residues in the carboxy-terminal domain of NS4B protein
J Aligo, S Jia, D Manna, KV Konan - Virology, 2009 - Elsevier
During replication, hepatitis C virus (HCV) NS4B protein rearranges intracellular membranes
to form foci, or the web, the putative site for HCV replication. To understand the role of the C…
to form foci, or the web, the putative site for HCV replication. To understand the role of the C…
[HTML][HTML] The role of simian virus 5 V protein on viral RNA synthesis
Y Lin, F Horvath, JA Aligo, R Wilson, B He - Virology, 2005 - Elsevier
The paramyxovirus simian virus 5 (SV5) has seven genes but encodes eight known viral
proteins. The V/P gene is transcribed into two mRNA species: V mRNA from a faithful …
proteins. The V/P gene is transcribed into two mRNA species: V mRNA from a faithful …
[HTML][HTML] Multiple poliovirus-induced organelles suggested by comparison of spatiotemporal dynamics of membranous structures and phosphoinositides
…, S Banerjee, D Aponte-Diaz, SD Sharma, J Aligo… - PLoS …, 2018 - journals.plos.org
At the culmination of poliovirus (PV) multiplication, membranes are observed that contain
phosphatidylinositol-4-phosphate (PI4P) and appear as vesicular clusters in cross section. …
phosphatidylinositol-4-phosphate (PI4P) and appear as vesicular clusters in cross section. …
[HTML][HTML] Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody
…, T Kirchner, K D'Aquino, R Nanjunda, J Aligo… - Molecular …, 2018 - Elsevier
Objective Insulin resistance is a key feature of Type 2 Diabetes (T2D), and improving insulin
sensitivity is important for disease management. Allosteric modulation of the insulin receptor …
sensitivity is important for disease management. Allosteric modulation of the insulin receptor …
Is murine gammaherpesvirus-68 (MHV-68) a suitable immunotoxicological model for examining immunomodulatory drug-associated viral recrudescence?
J Aligo, M Walker, P Bugelski… - Journal of …, 2015 - Taylor & Francis
Immunosuppressive agents are used for treatment of a variety of autoimmune diseases including
rheumatoid arthritis (RA), systemic lupus erythematosis (SLE), and psoriasis, as well as …
rheumatoid arthritis (RA), systemic lupus erythematosis (SLE), and psoriasis, as well as …