… For example, Boerckel and colleagues [66] recently evaluated the time course of bone
regeneration in a rat segmental bone defect model over 12 weeks to quantify the dynamics of …

The regeneration of bone in segmental defects has historically been a challenge in the
orthopedic field. In particular, a lack of vascular supply often leads to nonunion and avascular …

There is a growing need for successful bone tissue engineering strategies and advanced
biomaterials that mimic the structure and function of native tissues carry great promise. …

The treatment of challenging fractures and large osseous defects presents a formidable
problem for orthopaedic surgeons. Tissue engineering/regenerative medicine approaches seek …

Delivery of recombinant proteins is a proven therapeutic strategy to promote endogenous
repair mechanisms and tissue regeneration. Bone morphogenetic protein-2 (rhBMP-2) has …

New vascular network formation is a critical step in the wound healing process and a primary
limiting factor in functional tissue regeneration. Like many tissues, neovascular networks …

Local or systemic stem cell delivery has the potential to promote repair of a variety of damaged
or degenerated tissues. Although various stem cell sources have been investigated for …

Osteogenic growth factors that promote endogenous repair mechanisms hold considerable
potential for repairing challenging bone defects. The local delivery of one such growth factor, …

The functions of the paralogous transcriptional coactivators Yes-associated protein (YAP)
and transcriptional coactivator with PDZ-binding motif (TAZ) in bone are controversial. Each …

Large bone defects cannot form a callus and exhibit high complication rates even with the
best treatment strategies available. Tissue engineering approaches often use scaffolds …