User profiles for J. Chappell

Joe (Joseph) Chappell

University of Kentucky
Verified email at uky.edu
Cited by 12684

Sea level change through the last glacial cycle

K Lambeck, J Chappell - Science, 2001 - science.org
Sea level change during the Quaternary is primarily a consequence of the cyclic growth and
decay of ice sheets, resulting in a complex spatial and temporal pattern. Observations of this …

Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants

J Chappell - Annual review of plant biology, 1995 - annualreviews.org
… The feasibility of this approach was tested recently using tobacco cell culture mRNA to isolate
and sequence a partial squalene syn thetase cDNA clone (J Chappell, unpublished data). …

Isoprenoid biosynthesis in plants: carbon partitioning within the cytoplasmic pathway

JD Newman, J Chappell - Critical reviews in biochemistry and …, 1999 - Taylor & Francis
… and Chappell, J., Induction of sesquiterpene cyclase and suppression of squalene synthetase
activities in plant cell cultures treated with fungal elicitor, Plant Physiol., 88, 1291, 1988. 19…

[HTML][HTML] An mRNA vaccine against SARS-CoV-2—preliminary report

…, RN Coler, MP McCullough, JD Chappell… - New England journal …, 2020 - Mass Medical Soc
Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged
in late 2019 and spread globally, prompting an international effort to accelerate development …

[HTML][HTML] SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

…, JS McLellan, MR Denison, JD Chappell… - Nature, 2020 - nature.com
A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to
control the coronavirus disease 2019 (COVID-19) global pandemic. Structural studies have …

Association between mRNA vaccination and COVID-19 hospitalization and disease severity

…, HM Babcock, JH Kwon, N Halasa, JD Chappell… - Jama, 2021 - jamanetwork.com
Importance A comprehensive understanding of the benefits of COVID-19 vaccination requires
consideration of disease attenuation, determined as whether people who develop COVID-…

[HTML][HTML] Community-acquired pneumonia requiring hospitalization among US adults

…, EJ Anderson, DM Courtney, JD Chappell… - … England Journal of …, 2015 - Mass Medical Soc
Background Community-acquired pneumonia is a leading infectious cause of hospitalization
and death among US adults. Incidence estimates of pneumonia confirmed radiographically …

Oxygen isotopes and sea level

J Chappell, NJ Shackleton - Nature, 1986 - nature.com
… , sea level S, , = H, , – Ut, where H, , is the elevation of the crest of reef i on section j and t,
is the age of reef i. Sea levels have been estimated for the reef sequence at seven surveyed …

[HTML][HTML] Durability of responses after SARS-CoV-2 mRNA-1273 vaccination

…, PC Roberts, M Makhene, JD Chappell… - … England Journal of …, 2021 - Mass Medical Soc
Immunogenicity and the mRNA-1273 SARS-CoV-2 Vaccine Thirty-four adults received two
100-μg injections of the mRNA-1273 SARS-CoV-2 vaccine, and serum anti–spike protein …

[HTML][HTML] Community-acquired pneumonia requiring hospitalization among US children

…, Y Zhu, A Patel, W Hymas, JD Chappell… - … England Journal of …, 2015 - Mass Medical Soc
Background Incidence estimates of hospitalizations for community-acquired pneumonia
among children in the United States that are based on prospective data collection are limited. …