[HTML][HTML] Landscape of transcription in human cells
Eukaryotic cells make many types of primary and processed RNAs that are found either in
specific subcellular compartments or throughout the cells. A complete catalogue of these …
specific subcellular compartments or throughout the cells. A complete catalogue of these …
GENCODE: the reference human genome annotation for The ENCODE Project
The GENCODE Consortium aims to identify all gene features in the human genome using a
combination of computational analysis, manual annotation, and experimental validation. …
combination of computational analysis, manual annotation, and experimental validation. …
GENCODE reference annotation for the human and mouse genomes
…, A Bignell, S Carbonell Sala, J Chrast… - Nucleic acids …, 2019 - academic.oup.com
The accurate identification and description of the genes in the human and mouse genomes
is a fundamental requirement for high quality analysis of data informing both genome biology …
is a fundamental requirement for high quality analysis of data informing both genome biology …
The genome sequence of taurine cattle: a window to ruminant biology and evolution
…, A Astashyn, CE Chapple, HC Chen, J Chrast… - Science, 2009 - science.org
To understand the biology and evolution of ruminants, the cattle genome was sequenced to
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …
about sevenfold coverage. The cattle genome contains a minimum of 22,000 genes, with a …
[HTML][HTML] GENCODE: producing a reference annotation for ENCODE
… The identification of a rare splice variant in the C16orf35 gene at the alpha globin locus is
also facilitated using mouse EST evidence (J Hughes, personal communication). Importantly, …
also facilitated using mouse EST evidence (J Hughes, personal communication). Importantly, …
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11. 2 locus
…, HG Brunner, D Cailley, P Callier, J Chiesa, J Chrast… - Nature, 2011 - nature.com
Both obesity and being underweight have been associated with increased mortality 1 , 2 .
Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m 2 in adults and ≤ −2 …
Underweight, defined as a body mass index (BMI) ≤ 18.5 kg per m 2 in adults and ≤ −2 …
Angiotensin II induces skeletal muscle wasting through enhanced protein degradation and down-regulates autocrine insulin-like growth factor I
M Brink, SR Price, J Chrast, JL Bailey, A Anwar… - …, 2001 - academic.oup.com
We previously showed that angiotensin II (ang II) infusion in the rat produces cachexia and
decreases circulating insulin-like growth factor I (IGF-I). The weight loss derives from an …
decreases circulating insulin-like growth factor I (IGF-I). The weight loss derives from an …
Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions
This report presents systematic empirical annotation of transcript products from 399 annotated
protein-coding loci across the 1% of the human genome targeted by the Encyclopedia of …
protein-coding loci across the 1% of the human genome targeted by the Encyclopedia of …
[HTML][HTML] Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
…, T Dieterle, Y Ikeda, M Date, J Chrast… - The Journal of …, 2004 - Am Soc Clin Investig
Ablation or inhibition of phospholamban (PLN) has favorable effects in several genetic murine
dilated cardiomyopathies, and we showed previously that a pseudophosphorylated form …
dilated cardiomyopathies, and we showed previously that a pseudophosphorylated form …
Low number of fixed somatic mutations in a long-lived oak tree
…, C Iseli, S Calderon, C Gouhier-Darimont, J Chrast… - Nature Plants, 2017 - nature.com
… Kuhlemeier for sharing unpublished results, J. Tercier for tree-ring analysis, Transistor …
Guex for advice on SNV identification and J.-J. Strahm and M. Bonetti for providing oak …
Guex for advice on SNV identification and J.-J. Strahm and M. Bonetti for providing oak …