Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy
in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to …
in prostate cancer involves epithelial plasticity, in which tumor cells demonstrate low to …
Genomic correlates of clinical outcome in advanced prostate cancer
… CRPC-Adeno showing a high NEPC score/low AR signaling score (J). Tumors represented
in I and J were noted to have distinct nuclear features, including various degrees of nuclear …
in I and J were noted to have distinct nuclear features, including various degrees of nuclear …
Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy
Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of
innate and T cell–mediated anticancer immune responses. Here we demonstrate that …
innate and T cell–mediated anticancer immune responses. Here we demonstrate that …
[PDF][PDF] N-Myc induces an EZH2-mediated transcriptional program driving neuroendocrine prostate cancer
… J. Low magnification photomicrograph H&E image of 2 representative divergent …
Photomicrograph images of the 2 representative divergent differentiated divergent regions shown in …
Photomicrograph images of the 2 representative divergent differentiated divergent regions shown in …
[HTML][HTML] Patient derived organoids to model rare prostate cancer phenotypes
…, A Donoghue, M Kossai, D Gao, J Cyrta… - Nature …, 2018 - nature.com
A major hurdle in the study of rare tumors is a lack of existing preclinical models. Neuroendocrine
prostate cancer is an uncommon and aggressive histologic variant of prostate cancer …
prostate cancer is an uncommon and aggressive histologic variant of prostate cancer …
[HTML][HTML] Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling
Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical
phenotype. To define the biological features driving this phenotype, we performed an …
phenotype. To define the biological features driving this phenotype, we performed an …
Genomic landscape of adenoid cystic carcinoma of the breast
…, R Natrajan, L Fuhrmann, J Cyrta… - The Journal of …, 2015 - Wiley Online Library
Adenoid cystic carcinoma ( AdCC ) is a rare type of triple‐negative breast cancer ( TNBC )
characterized by the presence of the MYB–NFIB fusion gene. The molecular underpinning of …
characterized by the presence of the MYB–NFIB fusion gene. The molecular underpinning of …
Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings and review of the literature
J Cyrta, F Andreiuolo, S Azoulay, C Balleyguier… - …, 2013 - Wiley Online Library
Pure and mixed mucinous carcinoma of the breast: fine needle aspiration cytology findings
and review of the literature - Cyrta - 2013 - Cytopathology - Wiley Online Library …
and review of the literature - Cyrta - 2013 - Cytopathology - Wiley Online Library …
ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion
…, C Lodillinsky, A Castagnino, J Cyrta… - Journal of Cell …, 2015 - rupress.org
… Lodillinsky by a postdoctoral fellowship from Fondation Pierre-Gilles de Gennes pour la
Recherche; J. Cyrta by an MD Master 2 fellowship from Institut Curie; E. Infante by a postdoctoral …
Recherche; J. Cyrta by an MD Master 2 fellowship from Institut Curie; E. Infante by a postdoctoral …
[HTML][HTML] Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity
J Cyrta, A Augspach, MR De Filippo, D Prandi… - Nature …, 2020 - nature.com
Advanced prostate cancer initially responds to hormonal treatment, but ultimately becomes
resistant and requires more potent therapies. One mechanism of resistance observed in …
resistant and requires more potent therapies. One mechanism of resistance observed in …