Acute cholecystitis: a review
JR Gallaher, A Charles - Jama, 2022 - jamanetwork.com
Importance Gallbladder disease affects approximately 20 million people in the US. Acute
cholecystitis is diagnosed in approximately 200 000 people in the US each year. Observations …
cholecystitis is diagnosed in approximately 200 000 people in the US each year. Observations …
[HTML][HTML] A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation
Adaptive therapy is a dynamic cancer treatment protocol that updates (or ‘adapts’) treatment
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …
decisions in anticipation of evolving tumor dynamics. This broad term encompasses many …
Kemp elimination catalysts by computational enzyme design
…, L Jiang, J DeChancie, J Betker, JL Gallaher… - Nature, 2008 - nature.com
The design of new enzymes for reactions not catalysed by naturally occurring biocatalysts is
a challenge for protein engineering and is a critical test of our understanding of enzyme …
a challenge for protein engineering and is a critical test of our understanding of enzyme …
De novo computational design of retro-aldol enzymes
…, L Doyle, D Rothlisberger, A Zanghellini, JL Gallaher… - science, 2008 - science.org
The creation of enzymes capable of catalyzing any desired chemical reaction is a grand
challenge for computational protein design. Using new algorithms that rely on hashing …
challenge for computational protein design. Using new algorithms that rely on hashing …
Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction
…, G Kiss, AR Lambert, JL St. Clair, JL Gallaher… - Science, 2010 - science.org
The Diels-Alder reaction is a cornerstone in organic synthesis, forming two carbon-carbon
bonds and up to four new stereogenic centers in one step. No naturally occurring enzymes …
bonds and up to four new stereogenic centers in one step. No naturally occurring enzymes …
Computational protein design enables a novel one-carbon assimilation pathway
We describe a computationally designed enzyme, formolase (FLS), which catalyzes the
carboligation of three one-carbon formaldehyde molecules into one three-carbon …
carboligation of three one-carbon formaldehyde molecules into one three-carbon …
The Evolution of Quantum Confinement in CsPbBr3 Perovskite Nanocrystals
Colloidal nanocrystals (NCs) of lead halide perovskites are considered highly promising
materials that combine the exceptional optoelectronic properties of lead halide perovskites with …
materials that combine the exceptional optoelectronic properties of lead halide perovskites with …
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
…, Y Ashani, M Goldsmith, Y Song, JL Gallaher… - Nature chemical …, 2012 - nature.com
The ability to redesign enzymes to catalyze noncognate chemical transformations would
have wide-ranging applications. We developed a computational method for repurposing the …
have wide-ranging applications. We developed a computational method for repurposing the …
Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage
…, LA Lai, TA Brentnall, L Li, Z Feng, J Gallaher… - Gastroenterology, 2008 - Elsevier
Background & Aims: Telomere shortening is implicated in cancer and aging and might link
these 2 biologic events. We explored this hypothesis in ulcerative colitis (UC), a chronic …
these 2 biologic events. We explored this hypothesis in ulcerative colitis (UC), a chronic …
Computational design of catalytic dyads and oxyanion holes for ester hydrolysis
…, G Kiss, AP Kuzin, AJT Smith, J Gallaher… - Journal of the …, 2012 - ACS Publications
Nucleophilic catalysis is a general strategy for accelerating ester and amide hydrolysis. In
natural active sites, nucleophilic elements such as catalytic dyads and triads are usually …
natural active sites, nucleophilic elements such as catalytic dyads and triads are usually …