Sick sinus syndrome refers to a collection of disorders marked by the heart's inability to
perform its pacemaking function. Predominantly affecting older adults, sick sinus syndrome …

Large-scale two-hybrid screens have generated a wealth of information describing potential
protein–protein interactions. When compiled with data from systematic localizations of …

Prior work demonstrates that AKT activity regulates sensitivity of cells to G 1 arrest induced
by mammalian target of rapamycin (mTOR) inhibitors such as rapamycin and CCI-779. To …

… This article is dedicated to the memory of Sandor Gera who succumbed to glioblastoma
multiforme on October 17, 2006. … J Biol Chem … J Biol Chem …

Mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin and CCI-779, have
shown preclinical potential as therapy for multiple myeloma. By inhibiting expression of cell …

Although it is known that mTOR complex 2 (mTORC2) functions upstream of Akt, the role of
this protein kinase complex in cancer is not well understood. Through an integrated analysis …

Recent work identifies the AKT kinase as a potential mediator of tumor expansionin multiple
myeloma. The finding of PTEN mutations in several myeloma cell lines suggests that loss of …

… Hardy J. Membrane damage is at the core of Alzheimer's disease. Lancet Neurol 16(5):
342-… [100] Di Scala C, Yahi N, Lelievre C, Garmy N, Chahinian H, Fantini J. Biochemical …

10.7554/eLife.34317.001 Mechanistic and structural studies of membrane proteins require
their stabilization in specific conformations. Single domain antibodies are potent reagents for …

In vitro studies indicate the therapeutic potential of mTOR inhibitors in treating multiple
myeloma. To provide further support for this potential, we used the rapamycin analog CCI-779 in …