Large panels of comprehensively characterized human cancer models, including the Cancer
Cell Line Encyclopedia (CCLE), have provided a rigorous framework with which to study …

Elucidation of the mutational landscape of human cancer has progressed rapidly and been
accompanied by the development of therapeutics targeting mutant oncogenes. However, a …

Proteins are essential agents of biological processes. To date, large-scale profiling of cell line
collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily on …

CRISPR/Cas9 has emerged as a powerful new tool to systematically probe gene function.
We compared the performance of CRISPR to RNAi-based loss-of-function screens for the …

Interferons (IFNs) are cytokines that play a critical role in limiting infectious and malignant
diseases 1 , 2 , 3 – 4 . Emerging data suggest that the strength and duration of IFN signaling …

Background Parkinson disease (PD) is a neurodegenerative disease characterized by the
accumulation of alpha-synuclein (SNCA) and other proteins in aggregates termed “Lewy …

Anti-tumor efficacy of targeted therapies is variable across patients and cancer types. Even
in patients with initial deep response, tumors are typically not eradicated and eventually …

YAP is a key transcriptional co-activator of TEADs, it regulates cell growth and is frequently
activated in cancer. In Malignant Pleural Mesothelioma (MPM), YAP is activated by loss-of-…

Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal
adhesions and also in capping of actin filaments to regulate actin dynamics. Using molecular …

Perturbed epigenomic programs play key roles in tumorigenesis, and chromatin modulators
are candidate therapeutic targets in various human cancer types. To define singular and …