We have extended our understanding of the molecular biology that underlies adult glioblastoma
over many years. By contrast, high-grade gliomas in children and adolescents have …

Object The current treatment of craniopharyngiomas is evolving into one of a multimodal
approach in which the aim is disease control and improved preservation of quality of life (QOL). …

Astrocytic tumors account for 42% of childhood brain tumors, arising in all anatomical regions
and associated with neurofibromatosis type 1 (NF1) in 15%. Anatomical site determines …

We introduce Bootstrap Your Own Latent (BYOL), a new approach to self-supervised image
representation learning. BYOL relies on two neural networks, referred to as online and target …

Objectives Previous studies have shown that a single question may identify individuals with
inadequate health literacy. We evaluated and compared the performance of 3 health literacy …

We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse
intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 …

Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …

Two recurrent mutations, K27M and G34R/V, within histone variant H3.3 were recently identified
in ∼50% of pHGGs. Both mutations define clinically and biologically distinct subgroups …

Objective Gut microbiota metabolises bile acids (BA). As dysbiosis has been reported in
inflammatory bowel diseases (IBD), we aim to investigate the impact of IBD-associated …

Background Crohn’s disease (CD)-associated dysbiosis is characterised by a loss of
Faecalibacterium prausnitzii, whose culture supernatant exerts an anti-inflammatory effect both in …