Purpose: We report the diagnostic yield of whole-exome sequencing (WES) in 3,040 consecutive
cases at a single clinical laboratory. Methods: WES was performed for many different …

De novo mutations in protein-coding genes are a well-established cause of developmental
disorders 1 . However, genes known to be associated with developmental disorders account …

We report the development of a multiplex reverse transcription-polymerase chain reaction (RT-PCR)
method for the definitive identification of the body fluids that are commonly …

Conventional methods of body fluid identification use a variety of labor-intensive, technologically
diverse techniques that are performed in a series, not parallel, manner and are costly in …

Intellectual disability (ID) affects approximately 1%–3% of humans with a gender bias
toward males. Previous studies have identified mutations in more than 100 genes on the X …

An alternative approach to conventional protein‐based body fluid identification is gene
expression profiling analysis. In the present work, we report the development of sensitive and …

Importance Medication nonadherence accounts for up to half of uncontrolled hypertension.
Smartphone applications (apps) that aim to improve adherence are widely available but have …

Background: Sodium consumption raises blood pressure, increasing the risk for heart attack
and stroke. Several countries, including the United States, are considering strategies to …

Background Traditionally, clinical studies rely on brick-and-mortar sites to recruit participants.
Newer technology-based studies have utilized non-traditional virtual methods that can …

… Juusola, MS, offers additional insight into her original research article, "The Cost-Effectiveness
of Preexposure Prophylaxis for HIV Prevention in the United States in Men Who Have …