User profiles for J. Klughammer
Johanna KlughammerBroad Institute of MIT and Harvard Verified email at broadinstitute.org Cited by 5673 |
High-definition spatial transcriptomics for in situ tissue profiling
… P(c j |b) and P(b|c j ) represent the posterior probability and the likelihood, respectively. P(b)…
cell type j and respective Θ j , we retained only nonzero elements of each Θ j and shuffled …
cell type j and respective Θ j , we retained only nonzero elements of each Θ j and shuffled …
Specification of tissue-resident macrophages during organogenesis
…, CE Jacome-Galarza, K Händler, J Klughammer… - Science, 2016 - science.org
INTRODUCTION Embryonic development and tissue homeostasis depend on cooperation
between specialized cell types. Resident macrophages are professional phagocytes that …
between specialized cell types. Resident macrophages are professional phagocytes that …
Pooled CRISPR screening with single-cell transcriptome readout
… and stimulated conditions, respectively; and i and j are indices of the signature genes (n) and
… For m = 100, this is equivalent to μ a and μb being placed at index j = 20 and j = 80 of the Z …
… For m = 100, this is equivalent to μ a and μb being placed at index j = 20 and j = 80 of the Z …
[HTML][HTML] A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors
Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq)
profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq …
profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq …
Expansion sequencing: Spatially precise in situ transcriptomics in intact biological systems
…, BE Johnson, J Klughammer, M Slyper, J Waldman… - Science, 2021 - science.org
INTRODUCTION Cells and tissues are made up of diverse molecular building blocks,
organized with nanoscale precision over extended length scales. Newly developed techniques …
organized with nanoscale precision over extended length scales. Newly developed techniques …
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
…, AD Bretherick, TG Richardson, J Klughammer… - Nature …, 2021 - nature.com
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …
understand mechanisms underpinning gene regulation and disease. In the present study, we …
[HTML][HTML] Artemisinins target GABAA receptor signaling and impair α cell identity
…, RA Romanov, C Sturtzel, CH Lardeau, J Klughammer… - Cell, 2017 - cell.com
Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new
insulin-producing cells from other cell types is a major aim of regenerative medicine. One …
insulin-producing cells from other cell types is a major aim of regenerative medicine. One …
Epigenetic encoding, heritability and plasticity of glioma transcriptional cell states
…, LN Gonzalez Castro, AR Richman, J Klughammer… - Nature …, 2021 - nature.com
Single-cell RNA sequencing has revealed extensive transcriptional cell state diversity in
cancer, often observed independently of genetic heterogeneity, raising the central question of …
cancer, often observed independently of genetic heterogeneity, raising the central question of …
[PDF][PDF] Single-cell DNA methylome sequencing and bioinformatic inference of epigenomic cell-state dynamics
Methods for single-cell genome and transcriptome sequencing have contributed to our
understanding of cellular heterogeneity, whereas methods for single-cell epigenomics are much …
understanding of cellular heterogeneity, whereas methods for single-cell epigenomics are much …
The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space
Glioblastoma is characterized by widespread genetic and transcriptional heterogeneity, yet
little is known about the role of the epigenome in glioblastoma disease progression. Here, …
little is known about the role of the epigenome in glioblastoma disease progression. Here, …