Precise control of transcriptional programmes underlying metazoan development is modulated
by enzymatically active co-regulatory complexes, coupled with epigenetic strategies. One …

Nuclear receptors (NRs) repress transcriptional responses to diverse signaling pathways as
an essential aspect of their biological activities, but mechanisms determining the specificity …

… We also thank J. Hightower and M. Fisher for figure and manuscript preparation. … ., and
Wong, J. (2000). Both corepressor proteins SMRT and N-CoR exist in large protein complexes …

The nuclear receptor corepressor (NCoR) and the related factor known as silencing
mediator of retinoic acid and thyroid hormone receptor (SMRT) are essential components of …

Precise control of the innate immune response is required for resistance to microbial
infections and maintenance of normal tissue homeostasis. Because this response involves …

We have developed a highly sensitive, specific and reproducible method for microRNA (miRNA)
expression profiling, using the BeadArray™ technology. This method incorporates an …

The rapid emergence of SARS-CoV-2 variants raised public health questions concerning the
capability of diagnostic tests to detect new strains, the efficacy of vaccines, and how to map …

The extreme polarized morphology of neurons poses a challenging problem for intracellular
trafficking pathways. The distant synaptic terminals must communicate via axonal transport …

Background Macrophages (Mθ) play a central role in the innate immune response and in the
pathology of chronic inflammatory diseases. Macrophages treated with Th2-type cytokines …

Macrophages represent one of the primary targets of HIV-1 infection. Changes in gene
expression in primary human monocyte-derived macrophages following virus exposure were …