All modern humans use tools to overcome limitations of our anatomy and to make difficult tasks
easier. However, if tool use is such an advantage, we may ask why it is not evolved to the …

Temporomandibular joint (TMJ) dysfunction is a common condition that is best evaluated with
magnetic resonance (MR) imaging. The first step in MR imaging of the TMJ is to evaluate …

Resveratrol is a polyphenol which has been shown to have beneficial effects on metabolic
syndrome-related alterations in experimental animals, including glucose and lipid …

We assembled an ancestrally diverse collection of genome-wide association studies (GWAS)
of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non…

Metformin is widely used in the treatment of type 2 diabetes (T2D), but its mechanism of
action is poorly defined. Recent evidence implicates the gut microbiota as a site of metformin …

The popularization of large-scale genotyping projects has led to the widespread adoption of
genetic association studies as the tool of choice in the search for single nucleotide …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome-wide …

BACKGROUND: There is an increasing recognition that the pathophysiology of mental disorders
could be the result of deregulation of synaptic plasticity with alterations of neurotrophins…

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Archaeological research in the African rainforest reveals unexpected results in the search for
the origins of hominoid technology. The ancient Panin sites from Côte d'Ivoire constitute the …