User profiles for J. Nkwocha
 | Jewel NkwochaVirginia Commonwealth University Verified email at vcu.edu Cited by 160 |
Cotargeting BCL-2 and PI3K induces BAX-dependent mitochondrial apoptosis in AML cells
Inhibitors targeting BCL-2 apoptotic proteins have significant potential for the treatment of
acute myeloid leukemia (AML); however, complete responses are observed in only 20% of …
acute myeloid leukemia (AML); however, complete responses are observed in only 20% of …
Inflammation and monocyte recruitment due to aging and mechanical stretch in alveolar epithelium are inhibited by the molecular chaperone 4-phenylbutyrate
…, MB Schneck, K Shankar, J Nkwocha… - Cellular and molecular …, 2018 - Springer
Introduction Ventilator-Induced lung injury (VILI) is a form of acute lung injury that is initiated
or exacerbated by mechanical ventilation. The aging lung is also more susceptible to injury. …
or exacerbated by mechanical ventilation. The aging lung is also more susceptible to injury. …
IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB–and caspase-8–dependent mechanisms
Interactions between the inhibitor of apoptosis protein antagonist LCL161 and the histone
deacetylase inhibitor panobinostat (LBH589) were examined in human multiple myeloma (MM…
deacetylase inhibitor panobinostat (LBH589) were examined in human multiple myeloma (MM…
Dual mTORC1/2 inhibition synergistically enhances AML cell death in combination with the BCL2 antagonist venetoclax
Purpose: Acute myelogenous leukemia (AML) is an aggressive disease with a poor outcome.
We investigated mechanisms by which the anti-AML activity of ABT-199 (venetoclax) could …
We investigated mechanisms by which the anti-AML activity of ABT-199 (venetoclax) could …
Chk1 inhibition potently blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding activity, and activation of downstream targets in human multiple myeloma Cells
These findings identify a heretofore unrecognized link between the Chk1 and STAT3
pathways and suggest that Chk1 pathway inhibitors warrant attention as novel and potent …
pathways and suggest that Chk1 pathway inhibitors warrant attention as novel and potent …
Causes of death in patients with Burkitt's lymphoma-the role of supportive care in overall management.
IT Magrath, C Semawere, J Nkwocha - East African Medical Journal, 1974 - cabdirect.org
A retrospective survey of the cause of death in 84 patients with Burkitt's lymphoma (BL) has
shown that these fall into early and late categories. The former are patients with tumours …
shown that these fall into early and late categories. The former are patients with tumours …
[HTML][HTML] Synergistic Interactions between the Hypomethylating Agent Thio-Deoxycytidine and Venetoclax in Myelodysplastic Syndrome Cells
Interactions between the novel hypomethylating agent (HMA) thio-deoxycytidine (T-dCyd)
and the BCL-2 antagonist ABT-199 (venetoclax) have been examined in human …
and the BCL-2 antagonist ABT-199 (venetoclax) have been examined in human …
Mechanisms underlying synergism between circularized tumor necrosis factor‐related apoptosis inducing ligand and bortezomib in bortezomib‐sensitive or‐resistant …
… Yun Leng, Xiaoyan Hu and Lin Li performed in vitro and in vivo studies, carried out statistical
analyses, designed the figures, and wrote the manuscript; Jewel Nkwocha and Kanika …
analyses, designed the figures, and wrote the manuscript; Jewel Nkwocha and Kanika …
[HTML][HTML] Non-canonical role for the ataxia-telangiectasia-Rad3 pathway in STAT3 activation in human multiple myeloma cells
Purpose The goal of this study was to characterize the relationship between ATR and
STAT3 interactions in human multiple myeloma (MM) cells. Methods Various MM cell lines, …
STAT3 interactions in human multiple myeloma (MM) cells. Methods Various MM cell lines, …
Functional role of DNMT1 in the anti-leukemic effects of hypomethylating agents in AML cells
Patients with high-risk MDS (myelodysplastic syndrome) respond poorly to current therapies,
and generally die due to progression to AML (acute myelogenous leukemia) or succumb to …
and generally die due to progression to AML (acute myelogenous leukemia) or succumb to …