The evolutionary processes that drive universal therapeutic resistance in adult patients with
diffuse glioma remain unclear 1 , 2 . Here we analysed temporally separated DNA-…

Immortal cancer cell lines (CCLs) are the most widely used system for investigating cancer
biology and for the preclinical development of oncology therapies. Pharmacogenomic and …

The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite
instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair 1 …

… We define \(A_{i,j} = 1\), if cancer types i and j have the same phenotype (eg both are … and
\(A_{i,j} = 0\) otherwise. For weights, we set \(W_{i,j} = 1\) if cancer types i and j are immediately …

0.21. 0 New features weights is now a optional kwarg for parametric univariate models. all
univariate and multivariate parametric models now have ability to handle left, right and interval …

Background Triple negative breast cancer (TNBC) is aggressive with limited treatment options
upon recurrence. Molecular discordance between primary and metastatic TNBC has been …

… Plotting the population firing rate in terms of ρ/J results in a data collapse for sufficiently large
J, and we find good agreement between the model‐predicted firing rate dependence on ρ/J …

Yeasts can form multicellular patterns as they expand on agar plates, a phenotype that
requires a functional copy of the FLO11 gene. Although the biochemical and molecular …

… The dashed line is the leftmost line with constant J that intersects with the black curve. We
have called the value of J on this line Jm. The inset is population firing rate as a function of ρ/J, …

Three-dimensional (3D) organoid cultures are flexible systems to interrogate cellular growth,
morphology, multicellular spatial architecture, and cellular interactions in response to …