User profiles for J. Overton

James A. Overton

Knocean
Verified email at overton.ca
Cited by 3949

A global meta‐analysis of the relative extent of intraspecific trait variation in plant communities

…, J Messier, T Nakashizuka, JMC Overton… - Ecology …, 2015 - Wiley Online Library
… where p ij is the relative abundance of species j in community i, N ij and t ij are the number …
j in community i, and t ijk is the trait value of individual k in community i belonging to species j. …

[HTML][HTML] Advancing human genetics research and drug discovery through exome sequencing of the UK Biobank

…, JF Waring, CD Whelan, EA Tsai, JD Overton… - Nature …, 2021 - nature.com
The UK Biobank Exome Sequencing Consortium (UKB-ESC) is a private–public partnership
between the UK Biobank (UKB) and eight biopharmaceutical companies that will complete …

Transanal hemorrhoidal dearterialization: a systematic review

P Giordano, J Overton, F Madeddu… - Diseases of the colon …, 2009 - journals.lww.com
PURPOSE: Transanal hemorrhoidal dearterialization consists of a Doppler-guided ligation
of the distal branches of the rectal arteries. The aim of this review is to assess the current …

De novo mutations revealed by whole-exome sequencing are strongly associated with autism

…, Y Song, P El-Fishawy, RC Murtha, M Choi, JD Overton… - Nature, 2012 - nature.com
Multiple studies have confirmed the contribution of rare de novo copy number variations to
the risk for autism spectrum disorders 1 , 2 , 3 . But whereas de novo single nucleotide …

The immune epitope database (IEDB): 2018 update

R Vita, S Mahajan, JA Overton, SK Dhanda… - Nucleic acids …, 2019 - academic.oup.com
… James A Overton , James A Overton … Randi Vita, Swapnil Mahajan, James A Overton,
Sandeep Kumar Dhanda, Sheridan Martini, Jason R Cantrell, Daniel K Wheeler, Alessandro Sette, …

[HTML][HTML] Exome sequencing and analysis of 454,787 UK Biobank participants

…, WJ Salerno, AR Shuldiner, LA Lotta, JD Overton… - Nature, 2021 - nature.com
A major goal in human genetics is to use natural variation to understand the phenotypic
consequences of altering each protein-coding gene in the genome. Here we used exome …

The immune epitope database (IEDB) 3.0

R Vita, JA Overton, JA Greenbaum… - Nucleic acids …, 2015 - academic.oup.com
The IEDB, www.iedb.org , contains information on immune epitopes—the molecular targets
of adaptive immune responses—curated from the published literature and submitted by …

[HTML][HTML] Within-sibship genome-wide association analyses decrease bias in estimates of direct genetic effects

…, JD Overton, NL Pedersen, DJ Porteous, J Reid… - Nature …, 2022 - nature.com
Estimates from genome-wide association studies (GWAS) of unrelated individuals capture
effects of inherited variation (direct effects), demography (population stratification, assortative …

De novo mutations in histone-modifying genes in congenital heart disease

S Zaidi, M Choi, H Wakimoto, L Ma, J Jiang, JD Overton… - Nature, 2013 - nature.com
Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births
1 . Many cases occur sporadically and impair reproductive fitness, suggesting a role for de …

Use of niche models in invasive species risk assessments

…, AT Peterson, J Soberón, JM Overton… - Biological …, 2011 - Springer
Risk maps summarizing landscape suitability of novel areas for invading species can be
valuable tools for preventing species’ invasions or controlling their spread, but methods …