Recent advances have uncovered the general protein apparatus used by all eukaryotes for
intracellular transport, including secretion and endocytosis, and for triggered exocytosis of …

The two universally required components of the intracellular membrane fusion machinery,
SNARE and SM (Sec1/Munc18-like) proteins, play complementary roles in fusion. Vesicular …

Eukaryotic life depends on the spatial and temporal organization of cellular membrane systems.
Recent advances in understanding the machinery of vesicle transport have established …

Recombinant v- and t-SNARE proteins reconstituted into separate lipid bilayer vesicles
assemble into SNAREpins—SNARE complexes linking two membranes. This leads to …

The N-ethylmaleimide-sensitive fusion protein (NSF) and the soluble NSF attachment
proteins (SNAPs) appear to be essential components of the intracellular membrane fusion …

In neural systems, information is often carried by ensembles of cells rather than by individual
units. Optical indicators 1 provide a powerful means to reveal such distributed activity, …

The SNARE hypothesis holds that a transport vesicle chooses its target for fusion when a
soluble NSF attachment protein (SNAP) receptor on the vesicle (V-SNARE) pairs with its …

This article explores the methods by which practitioners have traditionally approached
international conflicts. Approaches focusing on the resources or the interests of the parties can be …

The success of physical biochemists almost 30 years ago in demonstrating the spontaneous
renaturation of many proteins established the fundamental principle that amino acid …

The components of biological membranes are asymmetrically distributed between the
membrane surfaces. Proteins are absolutely asymmetrical in that every copy of a polypeptide …