Background: There have been postmarketing reports of adverse cardiovascular events
associated with the use of varenicline, a widely used smoking cessation drug. We conducted a …

Cytokines exert a vast array of immunoregulatory actions critical to human biology and disease.
However, the desired immunotherapeutic effects of native cytokines are often mitigated …

Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety
of immune-related disorders. However, the widespread clinical use of cytokines has been …

The Tyrolean Iceman, a 5,300-year-old Copper age individual, was discovered in 1991 on
the Tisenjoch Pass in the Italian part of the Ötztal Alps. Here we report the complete genome …

The use of ligands to tune the reactivity and selectivity of transition metal catalysts for C(sp 3
)–H bond functionalization is a central challenge in synthetic organic chemistry. Herein, we …

We describe a de novo computational approach for designing proteins that recapitulate the
binding sites of natural cytokines, but are otherwise unrelated in topology or amino acid …

To optimize drug candidates, modern medicinal chemists are increasingly turning to an
unconventional structural motif: small, strained ring systems. However, the difficulty of introducing …

Herein we report the synthesis of pyrroloindolines via a catalytic enantioselective formal [3+2]
cycloaddition of C(3)-substituted indoles. This methodology utilizes 4-aryl-1-sulfonyl-1,2,3-…

A variational principle is formulated for the inverse problem of full-field reconstruction of
three-dimensional plate/shell deformations from experimentally measured surface strains. The …

Classifying individual bacterial species comprising complex, polymicrobial patient specimens
remains a challenge for culture-based and molecular microbiology techniques in common …