Background Poly(adenosine diphosphate–ribose) polymerase inhibitors target cancers with
defects in homologous recombination repair by synthetic lethality. New therapies are …

Similar to functional magnetic resonance imaging (fMRI), functional near-infrared spectroscopy
(fNIRS) detects the changes of hemoglobin species inside the brain, but via differences …

PURPOSE Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor approved for advanced
breast cancer. In the adjuvant setting, the potential value of adding palbociclib to endocrine …

PURPOSE The National Cancer Institute Molecular Analysis for Therapy Choice (NCI-MATCH)
trial, the largest national precision oncology study to date (> 1,100 sites) of patients with …

Excess of body fat, or obesity, is a major health problem and confers a higher risk of cardiovascular
and metabolic disorders such as diabetes, hypertension, and coronary heart disease…

The sequence of events in haematogenous metastasis from colonic carcinoma was analysed,
using 1541 necropsy reports from 16 centres. The findings are consistent with the cascade …

Importance Previous communication has reported significant improvement in overall survival
(OS) when using doxorubicin plus sorafenib in the treatment of advanced hepatocellular …

Discovery of earth-abundant electrocatalysts to replace iridium for the oxygen evolution
reaction (OER) in a proton exchange membrane water electrolyzer (PEMWE) represents a …

PURPOSE To examine the association of gain-of-function (GOF) and non–gain-of-function (non-GOF)
TP53 mutations with prognosis of metastatic right-sided (RCC) versus left-sided …

Background Financial toxicity is a growing problem in oncology, but no prior studies have
prospectively measured the financial impact of cancer treatment in a diverse national cohort of …