… JA Surtees and JL Argueso contributed equally to this work. JAS is a Research Fellow of
the National Cancer Institute of Canada supported with funds provided by the Terry Fox Run. …

The ability of proteins to locate specific sites or structures among a vast excess of nonspecific
DNA is a fundamental theme in biology. Yet the basic principles that govern these …

Crossing over between homologous chromosomes is initiated in meiotic prophase in most
sexually reproducing organisms by the appearance of programmed double strand breaks …

… 146 Surtees and Funnell movement of these chromosomes with DNA replication and cell
division. Cell biology techniques have illustrated that plasmids and chromosomes are …

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step in nucleotide biosynthesis
and plays a central role in genome maintenance. Although a number of regulatory …

Genetic studies in Saccharomyces cerevisiae predict that the mismatch repair (MMR) factor
MSH2-MSH3 binds and stabilizes branched recombination intermediates that form during …

Over the past 180 years there has been a significant number of crowd-related bridge collapses
around the world. Barring natural disasters or human conflict, they have involved greater …

Crossing over between homologs is initiated in meiotic prophase by the formation of DNA
double-strand breaks that occur throughout the genome. In the major interference-responsive …

DNA-binding proteins search for specific targets via facilitated diffusion along a crowded
genome. However, little is known about how crowded DNA modulates facilitated diffusion and …

Mismatch repair (MMR) is initiated by MutS family proteins (MSH) that recognize DNA
mismatches and recruit downstream repair factors. We used a single-molecule DNA-unzipping …