Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

In many organisms, recombination rates differ between the two sexes. Here we show that in
mice, this is because of a shorter genomic interference distance in females than in males, …

Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by
dangerously low body weight. Neither candidate gene studies nor an initial genome-wide …

Many common illnesses, for reasons that have not been identified, differentially affect men
and women. For instance, the autoimmune diseases systemic lupus erythematosus (SLE) and …

We designed a high-density mouse genotyping array containing 623,124 single-nucleotide
polymorphisms that captures the known genetic variation present in the laboratory mouse. …

Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic
etiology. Previous genome-wide surveys have revealed a greater burden of large, rare copy …

Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and
function differ, on average, between people with schizophrenia and healthy individuals. As …

A number of large, rare copy number variants (CNVs) are deleterious for neurodevelopmental
disorders, but large, rare, protective CNVs have not been reported for such phenotypes. …

Clozapine is a particularly effective antipsychotic medication but its use is curtailed by the
risk of clozapine-induced agranulocytosis/granulocytopenia (CIAG), a severe adverse drug …