User profiles for J. Thorpe

Julian Robert Thorpe

DPhil University of Sussex
Verified email at Sussex.ac.uk
Cited by 3698

The molecular clock hypothesis: biochemical evolution, genetic differentiation and systematics

JP Thorpe - Annual Review of Ecology and Systematics, 1982 - annualreviews.org
… errors of S is discussed by Thorpe (316). The interlocus … ) I is not simple and is discussed
by Thorpe (316). Empirical tests … Thorpe's D has the property of triangle inequality (192). This …

[HTML][HTML] Gravitational-wave physics and astronomy in the 2020s and 2030s

…, X Siemens, DH Shoemaker, J Thorpe… - Nature Reviews …, 2021 - nature.com
The 100 years since the publication of Albert Einstein’s theory of general relativity saw
significant development of the understanding of the theory, the identification of potential …

The “metabolic memory”: is more than just tight glucose control necessary to prevent diabetic complications?

A Ceriello, MA Ihnat, JE Thorpe - The Journal of Clinical …, 2009 - academic.oup.com
Context: The concept of a “metabolic memory,” that is of diabetic vascular stresses persisting
after glucose normalization, has been supported both in the laboratory and in the clinic and …

[HTML][HTML] Safety and immunogenicity of seven COVID-19 vaccines as a third dose (booster) following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK (COV …

…, J Evans, H Baker, J Thorpe, S Batham, J Hailstone… - The Lancet, 2021 - thelancet.com
Background Few data exist on the comparative safety and immunogenicity of different
COVID-19 vaccines given as a third (booster) dose. To generate data to optimise selection of …

[HTML][HTML] The Sorcerer II Global Ocean Sampling Expedition: Northwest Atlantic through Eastern Tropical Pacific

…, H Baden-Tillson, C Stewart, J Thorpe, J Freeman… - PLoS …, 2007 - journals.plos.org
The world's oceans contain a complex mixture of micro-organisms that are for the most part,
uncharacterized both genetically and biochemically. We report here a metagenomic study of …

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

…, A Strange, E Sundqvist, V Thijs, J Thorpe… - Nature …, 2013 - nature.com
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple
sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 …

Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study

…, S Darby, M Peterson, AA Mukhtar, JG Thorpe… - The Lancet …, 2019 - thelancet.com
Background Despite improvements in multidisciplinary management, patients with biliary
tract cancer have a poor outcome. Only 20% of patients are eligible for surgical resection with …

Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients

A Ceriello, K Esposito, L Piconi, MA Ihnat, JE Thorpe… - Diabetes, 2008 - Am Diabetes Assoc
OBJECTIVE—To explore the possibility that oscillating glucose may outweigh A1C levels in
determining the risk for cardiovascular diabetes complications. RESEARCH DESIGN AND …

[HTML][HTML] Distinct tau prion strains propagate in cells and mice and define different tauopathies

…, H Mirbaha, A Li, SJ Barker, AC Foley, JR Thorpe… - Neuron, 2014 - cell.com
Prion-like propagation of tau aggregation might underlie the stereotyped progression of
neurodegenerative tauopathies. True prions stably maintain unique conformations ("strains") in …

Sub-Femto- Free Fall for Space-Based Gravitational Wave Observatories: LISA Pathfinder Results

…, R Stanga, F Steier, T Sumner, D Texier, JI Thorpe… - Physical review …, 2016 - APS
We report the first results of the LISA Pathfinder in-flight experiment. The results
demonstrate that two free-falling reference test masses, such as those needed for a space-based …