10.7554/eLife.08848.001 Somatic cell nuclear transfer has established that the oocyte contains
maternal factors with epigenetic reprogramming capacity. Yet the identity and function of …

Epigenetic modifications are implicated in the maintenance and regulation of transcriptional
memory by marking genes that were previously transcribed to facilitate transmission of these …

Mothers contribute cytoplasmic components to their progeny in a process called maternal
provisioning. Provisioning is influenced by the parental environment, but the molecular …

Genomically imprinted loci are expressed mono-allelically, dependent upon the parent of
origin. Their regulation not only illuminates how chromatin regulates gene expression but also …

Classically, the concept of inheritance has been restricted to the passage of DNA. However,
in the past couple of decades, have come to understand that information associated with …

Meng Zhang (Yale University) reported on her progress in characterizing the role of PUF
family proteins in neurogenesis. Although the PUF proteins are known to act in germline stem …

… [1] and Jadiel Wasson et al. [2] deplete the maternal stores of this enzyme using genetic
methods and a pharmacological inhibitor. Depletion of KDM1A resulted in arrest of embryos at …