A complete understanding of how exposure to environmental substances promotes cancer
formation is lacking. More than 70 years ago, tumorigenesis was proposed to occur in a two-…

Although a number of transfection experiments have suggested potential targets for the action
of the E2F1 transcription factor, as is the case for many transcriptional regulatory proteins, …

E2F transcription activity is composed of a family of heterodimers encoded by distinct genes.
Through the overproduction of each of the five known E2F proteins in mammalian cells, we …

A variety of results point to the transcription factor E2F as a critical determinant of the G1/S-phase
transition during the cell cycle in mammalian cells, serving to activate the transcription …

Since the discovery almost fifteen years ago that E2F transcription factors are key targets of
the retinoblastoma protein (RB), studies of the E2F family have uncovered critical roles in the …

Considerable evidence points to a role for Gl cyclin-dependent kinase (CDK) in allowing the
accumulation of E2F transcription factor activity and induction of the S phase of the cell …

Various experiments have demonstrated a collaborative action of Myc and Ras, both in normal
cell growth control as well as during oncogenesis. We now show that Ras enhances the …

Alterations of various components of the cell cycle regulatory machinery that controls the
progression of cells from a quiescent to a growing state contribute to the development of many …

Previous work has demonstrated the important role of E2F transcription activity in the induction
of S phase during the transition from quiescence to proliferation. In addition to the E2F-…

In this study we interrogated the metabolome of human acute myeloid leukemia (AML) stem
cells to elucidate properties relevant to therapeutic intervention. We demonstrate that amino …