RNA interference (RNAi) has become a powerful technique for reverse genetics and drug
discovery, and in both of these areas large-scale high-throughput RNAi screens are commonly …

The Minimum Information for Biological and Biomedical Investigations (MIBBI) project aims
to foster the coordinated development of minimum-information checklists and provide a …

We report for the first time the genomics of a nuclear compartment of the eukaryotic cell. 454
sequencing and microarray analysis revealed the pattern of nucleolus-associated chromatin …

There is a critical need for standard approaches to assess, report and compare the technical
performance of genome-scale differential gene expression experiments. Here we assess …

Background & Aims Carcinogen-induced mouse models of liver cancer are used
extensively to study the pathogenesis of the disease and are critical for validating candidate …

Motivation: The Oxford Nanopore MinION device represents a unique sequencing technology.
As a mobile sequencing device powered by the USB port of a laptop, the MinION has …

Recent results from large-scale genomic projects suggest that allele frequencies, which are
highly relevant for medical purposes, differ considerably across different populations. The …

Pathogenic variants in BRCA1 or BRCA2 are identified in ∼20% of families with multiple
individuals affected by early-onset breast and/or ovarian cancer. Extensive searches for …

During genome replication, polymerase epsilon (Pol ε) acts as the major leading-strand DNA
polymerase. Here we report the identification of biallelic mutations in POLE, encoding the …

Long non-coding RNAs (lncRNAs) constitute a large, yet mostly uncharacterized fraction of
the mammalian transcriptome. Such characterization requires a comprehensive, high-quality …