Objective: A recent study provisionally identified numerous genetic variants as risk factors for
the transition from smoking to the development of nicotine dependence, including an amino …

Genome-wide association studies (GWAS) have identified several risk variants for late-onset
Alzheimer's disease (LOAD) 1 , 2 . These common variants have replicable but small effects …

Several correlated phenotypes, alcohol dependence, major depressive syndrome, and an
endophenotype of electrophysiological measurements, event-related oscillations (EROs), …

A genome-wide survival analysis of 14,406 Alzheimer's disease (AD) cases and 25,849
controls identified eight previously reported AD risk loci and 14 novel loci associated with age at …

Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4
cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 …

Understanding the tissue-specific genetic controls of protein levels is essential to uncover
mechanisms of post-transcriptional gene regulation. In this study, we generated a genomic …

Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and
without Alzheimer disease (AD; n control = 13; n AD = 83) from the Knight Alzheimer Disease …

Genetic studies of Alzheimer disease (AD) have prioritized variants in genes related to the
amyloid cascade, lipid metabolism, and neuroimmune modulation. However, the cell-specific …

More than 20 genetic loci have been associated with risk for Alzheimer’s disease (AD), but
reported genome-wide significant loci do not account for all the estimated heritability and …

Nicotine dependence risk and lung cancer risk are associated with variants in a region of
chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, …