We present a hierarchical genome-assembly process (HGAP) for high-quality de novo microbial
genome assemblies using only a single, long-insert shotgun DNA library in conjunction …

Understanding the spread and evolution of pathogens is important for effective public health
measures and surveillance. Nextstrain consists of a database of viral genomes, a …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed
as therapeutics and are a major contributor to neutralizing antibody responses elicited …

The human genome is arguably the most complete mammalian reference assembly 1 , 2 , 3
, yet more than 160 euchromatic gaps remain 4 , 5 , 6 and aspects of its structural variation …

After its emergence in Wuhan, China, in late November or early December 2019, the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus rapidly spread globally. …

In an effort to more fully understand the full spectrum of human genetic variation, we
generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human …

We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected
by simplex autism. For the majority of these families, no copy-number variant (CNV) or …

INTRODUCTION Most studies of human genetic variation have focused on single-nucleotide
variants (SNVs). However, copy-number variants (CNVs) affect more base pairs of DNA …

Gibbons are small arboreal apes that display an accelerated rate of evolutionary chromosomal
rearrangement and occupy a key node in the primate phylogeny between Old World …