Diverse inhibitory neurons in the mammalian brain shape circuit connectivity and dynamics
through mechanisms of synaptic plasticity. Inhibitory plasticity can establish excitation/…

Synaptic strength depresses for low and potentiates for high activation of the postsynaptic
neuron. This feature is a key property of the Bienenstock–Cooper–Munro (BCM) synaptic …

Memory of cues associated with threat is critical for survival and a leading model for elucidating
how sensory information is linked to adaptive behavior by learning. Although the brain-…

Homeostasis is indispensable to counteract the destabilizing effects of Hebbian plasticity.
Although it is commonly assumed that homeostasis modulates synaptic strength, membrane …

Despite advances in experimental and theoretical neuroscience, we are still trying to identify
key biophysical details that are important for characterizing the operation of brain circuits. …

Synaptic inputs on cortical dendrites are organized with remarkable subcellular precision at
the micron level. This organization emerges during early postnatal development through …

Excitation in neural circuits must be carefully controlled by inhibition to regulate information
processing and network excitability. During development, cortical inhibitory and excitatory …

… Julijana Gjorgjieva Julijana Gjorgjieva is a postdoctoral research fellow at the Center for
Brain Science of Harvard University, in Cambridge, Massachusetts. She uses theoretical and …

In many sensory systems, the neural signal splits into multiple parallel pathways. For example,
in the mammalian retina, ∼20 types of retinal ganglion cells transmit information about …

Spontaneous activity drives the establishment of appropriate connectivity in different circuits
during brain development. In the mouse primary visual cortex, two distinct patterns of …