Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death
worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were …

Liver cancer, which is most often associated with virus infection, is prevalent worldwide, and
its underlying etiology and genomic structure are heterogeneous. Here we provide a whole-…

The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…

It is critical, but difficult, to catch the small variation in genomic or other kinds of data that
differentiates phenotypes or categories. A plethora of data is available, but the information from …

Cilia and flagella play important roles in many physiological processes, including cell and
fluid movement, sensory perception, and development [1]. The biogenesis and maintenance …

Cilia are slender microtubule-based appendages that emanate from the surfaces of a large
proportion of eukaryotic cells. The motile and non-motile forms of cilia represent bona fide …

Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma show
varying degrees of biliary epithelial differentiation, which can be defined as liver cancer …

We report the analysis of a Japanese male using high-throughput sequencing to ×40 coverage.
More than 99% of the sequence reads were mapped to the reference human genome. …

Background & Aims Patients with hepatocellular carcinoma (HCC) have a high-risk of multi-centric
(MC) tumor occurrence due to a strong carcinogenic background in the liver. In …

Whole exome sequencing (WXS) is widely used to identify causative genetic mutations of
diseases. However, not only have several commercial human exome capture platforms been …