TRADITIONALLY, the term "prerenal failure" was used to describe a clinical situation in which
the structurally intact kidney fails as a result of an impairment in glomerular perfusion. The …

Increasing attention has focused on the role of free radicals derived from oxygen in the
pathophysiology of a wide variety of disorders. One of the well-recognized targets of free radical-…

… allowed for the calculation of unique values for Kf in all the experimental animals. The
administration of8-… Blair, and KF Badr. 1990. Predominant functional roles for thromboxane A2 and …

… decline in theglomerular capillary ultrafiltration coefficient (Kf), which was also confined to …
, the latter also a consequence of the fall in Kf. In a separate group of seven PAN-treated rats, …

… The glomerular ultrafiltration coefficient(Kf) fell from 0.097±0.035 to 0.031±0.011 nl/(s * mmHg)
… It lowers Kf and contracts mesangial cells, likely through stimulation of IP3 generation and …

We recently reported the discovery that a series of novel prostaglandin (PG)F2-like compounds
(F2-isoprostanes) are produced in vivo independent of the cyclooxygenase as products …

These studies examine the in vivo formation of a unique series of PGF2-like compounds (F2-isoprostanes)
derived from free radical-catalyzed nonenzymatic peroxidation of arachidonic …

15-Lipoxygenase (15-LO) catalyzes hydroperoxidation of fatty acids, a reaction of potential
relevance to inflammation, membrane remodeling, and atherosclerosis. In human leukocytes, …

The isoprostanes are nonenzymatically generated prostanoids synthesized in vivo in
humans and rats through reactions catalyzed by free oxygen radicals. 8-Epi-prostaglandin F2 …

Free-radical–generated F 2 -isoprostane stimulates cell proliferation and endothelin-1
expression on endothelial cells. Background Free-radical–generated F 2 -isoprostane stimulates …